TRPV4 and KCaion channels functionally couple as osmosensors in the paraventricular nucleus

TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus

BACKGROUND AND PURPOSE Transient receptor potential vanilloid type 4 (TRPV4) and calcium-activated potassium channels (KCa ) mediate osmosensing in many tissues. Both TRPV4 and KCa channels are found in the paraventricular nucleus (PVN) of the hypothalamus, an area critical for sympathetic control of cardiovascular and renal function. Here, we have investigated whether TRPV4 channels functional...

Attenuated Dopaminergic Tone in the Paraventricular Nucleus

Contributing to Sympatho-Excitation in Rats with Type 2 Diabetes 3 Hong Zheng, Xuefei Liu, Yulong Li, Paras K Mishra and Kaushik P Patel 4 5 Department of Cellular and Integrative Physiology, Department of Emergency Medicine, 6 University of Nebraska Medical Center, Omaha, Nebraska 68198-5850 7 8 9 10 Running title: Central nervous system regulation of sympatho-excitation in diabetes 11 12 13 C...

Glutamatergic Innervation of the Supraoptic Nucleus, the Paraventricular Nucleus and the Supramamillary Nucleus of the Rat

a fundamental study of "histiriographic metafiction", and "literary genres", as introduced in "new historical philosophy", and tracing them in the works of julian barnes.

abstract a fundamental study of “historio-graphic metafiction” and “literary genres”, as introduced in “new historical philosophy”, and tracing them in the works of julian barnes having studied the two novels, the porcupine and arthur & george, by julian barnes, the researcher has applied linda hutcheon’s historio-graphic metafictional theories to them. the thesis is divided into five cha...

Substance P targets sympathetic control neurons in the paraventricular nucleus.

The paraventricular nucleus (PVN) contains spinally-projecting neurons implicated in fine-tuning the cardiovascular system. In vivo activity of "presympathetic" parvocellular neurons is suppressed by tonic inhibition from GABA-ergic inputs, inhibition of which increases sympathetic pressor activity and heart rate. Targeting of this specific neuronal population could potentially limit elevations...